biologyscienceТимирязевский биологический журналTimiryazev Biological Journal2949-4710ФГБОУ ВО РГАУ-МСХА имени К.А. Тимирязева (ФГБОУ ВО РГАУ-МСХА имени К.А. Тимирязева)10.26897/2949-4710-2025-3-2-4-01biologyscience-229Research Article4 - ЗООЛОГИЯ, ФИЗИОЛОГИЯ ЧЕЛОВЕКА И ЖИВОТНЫХ4 - ZOOLOGY, HUMAN AND ANIMAL PHYSIOLOGYОсобенности регуляции гемодинамики у кроликов при парентеральном введении трипсинаFeatures of hemodynamic regulation in rabbits during parenteral administration of trypsinhttps://orcid.org/0009-0000-6704-5367ГалыгаСемён ДмитриевичGaligaSemyon D.

Семён Дмитриевич Галыга, аспирант кафедры физиологии, этологии и биохимии животных, Российский государственный аграрный университет – МСХА имени К.А. Тимирязева; 127434, Москва, ул. Тимирязевская, 49

Semyon D. Galiga, post-graduate student of the Department of Physiology, Ecology and Biochemistry of Animals, Russian State Agrarian University – Moscow Timiryazev Agricultural Academy; 49 Timiryazevskaya St., Moscow, 127434, Russian Federation

ya.sokrat@mail.ruhttps://orcid.org/0009-0009-6485-7146КарамушкинаСветлана ВладимировнаKaramushkinaSvetlana V.

Светлана Владимировна Карамушкина, доцент кафедры физиологии, этологии и биохимии животных, кандидат биологических наук, доцент, Российский государственный аграрный университет – МСХА имени К.А. Тимирязева; 127434, Москва, ул. Тимирязевская 49

Svetlana V. Karamushkina, CSc (Bio), Associate Professor, Associate Professor at the Department of Physiology, Ecology and Biochemistry of Animals, Russian State Agrarian University – Moscow Timiryazev Agricultural Academy; 49 Timiryazevskaya St., Moscow, 127434, Russian Federation

https://orcid.org/0009-0004-6287-3971КралининаАлександра ВикторовнаKralininaAleksandra V.

Александра Викторовна Кралинина, лаборант кафедры физиологии, этологии и биохимии животных, бакалавр по специальности «Биология», Российский государственный аграрный университет – МСХА имени К.А. Тимирязева; 127434, Москва, ул. Тимирязевская 49

Aleksandra V. Kralinina, Laboratory Assistant at the Department of Physiology, Ecology and Biochemistry of Animals, BSc (Bio), Russian State Agrarian University – Moscow Timiryazev Agricultural Academy; 49 Timiryazevskaya St., Moscow, 127434, Russian Federation

Российский государственный аграрный университет – МСХА имени К.А. ТимирязеваРоссияRussian State Agrarian University – Moscow Timiryazev Agricultural AcademyRussian Federation20251511202532202532401202532401Copyright © Галыга С.Д., Карамушкина С.В., Кралинина А.В., 20252025Галыга С.Д., Карамушкина С.В., Кралинина А.В.Galiga S.D., Karamushkina S.V., Kralinina A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bioscience-journal.com/jour/article/view/229

Широкое применение трипсина обусловлено в основном его протеолитическим, противовоспалительным и противоотечным действием. В настоящей работе впервые показано воздействие кристаллического трипсина при парентеральном введении кроликам на процессы гемодинамики с целью изучения особенностей регуляции гемодинамики. Исследования проводились на 15 кроликах, которым внутримышечно или внутривенно вводился раствор трипсина в дозе 0,25 мг/кг живой массы. При сравнительном анализе показателей гемодинамики было выявлено, что раствор кристаллического трипсина при его внутримышечном введении оказывает вазодилатирующий эффект, который сопровождается достоверным снижением артериального давления (систолического – на 13%, диастолического – на 12%) и повышением частоты сердечных сокращений на 8% у кроликов. При внутривенном введении трипсина наблюдается кратковременный гипотензивный эффект, который компенсируется в течение 30 мин активацией симпатической нервной системы. Полученные данные расширяют представление о механизмах действия трипсина на сердечно-сосудистую систему и обосновывают возможность его применения в ветеринарной медицине для коррекции микроциркуляторных нарушений.

Trypsin is widely used for its proteolytic, anti-inflammatory, and decongestant properties. In this study, we investigated, for the first time, the effects of crystalline trypsin on hemodynamics in rabbits after parenteral administration, aiming to elucidate features of hemodynamic regulation. The study involved 15 rabbits, which received either an intramuscular (IM) or intravenous (IV) administration of trypsin solution at a dose of 0.25 mg/kg body weight. Comparative analysis of hemodynamic parameters revealed that intramuscular administration of crystalline trypsin solution induced a vasodilating effect, accompanied by a significant decrease in blood pressure (13% systolic, 12% diastolic) and an 8% increase in heart rate in rabbits. Intravenous administration of trypsin resulted in a short-term hypotensive effect, which was compensated within 30 minutes by activation of the sympathetic nervous system. These findings enhance our understanding of trypsin’s mechanisms of action on the cardiovascular system and support its potential application in veterinary medicine for correcting microcirculatory disorders.

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The authors declare that there are no conflicts of interest present.