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Application of sweeteners in pig feeding: a bibliographic review

https://doi.org/10.26897/2949-4710-2025-3-1-4-03

Abstract

Application of sweeteners as feed additives to increase the attractiveness of feed is a safe, physiological, relevant and cost-effective method to improve feed quality of feed and increase animal productivity. Despite their widespread use, however, only a few studies on the use of sweeteners in animals have been published by domestic authors. Thus, this study aimed to provide a bibliographic review of scientific data on the use of sweeteners in pig feeding, to understand their effects on physiological processes and functions in animals, and to determine their pros and cons. To identify relevant studies, a combination of search queries using the keywords “sweeteners,” “pigs,” “physiology,” “feed additives,” and “intensive sweeteners” was used in the PubMed Advanced Search Builder, Scopus, Web of Science Core Collection, and ELibrary databases. As a result, a list of 38 relevant scientific papers was obtained. The significant number of analyzed sources devoted to studying the effectiveness and safety of various sweeteners for feeding different animal species and humans shows existing knowledge gaps and suggests the need for further research to better understand the role of sweeteners in the physiology and nutrition of pigs. This paper discusses the effects of various sweeteners on pigs’ bodies and the feasibility of using them on pig farms. It also explores ways to increase their effectiveness, such as using mixtures of sweeteners with different ratios, using various sweeteners with different feeds, and developing mixtures for pigs’ specific needs based on sex, age, breed, and purpose. Additionally, it discusses developing complex feed additives containing flavoring compounds.

About the Authors

V. I. Maksimov
Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin
Russian Federation

Vladimir Il. Maksimov Professor, Doctor of Biological Sciences, Professor of department of Physiology, Pharmacology and Toxicology A.N. Golikov and I.E. Mozgov, FSBEI HE MGAVMiB – MBA named after K.I. Scriabin

Moscow



M. A. Volkova
Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin
Russian Federation

Margarita A. Volkova, 4th year graduate student of the Faculty of Veterinary Medicine, Department of Physiology, Pharmacology and Toxicology named after A.N. Golikov and I.E. Mozgov FSBEI HE MGAVMiB – MBA named after K.I. Scriabin

Moscow



K. A. Erkhova
Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin
Russian Federation

Ksenia A. Erkhova, 4th year 1st group student of the Faculty of Ecology and Biotechnology, FSBEI HE MGAVMiB – MBA named after K.I. Scriabin

Moscow



References

1. Deltsov A.A., Belova K.O. Analytical review of the market for iodinecontaining feed additives for animals. Veterinariya, zootekhniya i biotekhnologiya. 2024(3):12-22. (In Russ.) https://doi.org/10.36871/vet.zoo.bio.202403002

2. Hellekant G., Danilova V. Taste in domestic pig, Sus scrofa. Journal of Animal Physiology and Animal Nutrition. 1999;82:8-24. https://doi.org/10.1046/j.1439-0396.1999.00206.x

3. Kai-Jing Y. Effects of different sweeteners on behavior and neurotransmitters release in mice. Journal of Food Science and Technology. 2020;57(1):113-121. https://doi.org/10.1007/s13197-019-04036-6

4. Jansen M.R., Kim K. Evaluating the Effects of Non-Nutritive Sweeteners on Pigs: A Systematic Review. Animals. 2024;14:3032. https://doi.org/10.3390/ani14203032

5. Kennedy J.M., Baldwin B.A. Taste preferences in pigs for nutritive and non-nutritive sweet solutions. Animal Behaviour. 1972;20:706-718. https://doi.org/10.1016/S0003-3472(72)80142-8

6. McLaughlin C.L., Baile C.A., Buckholtz L.L., Freeman S.K. Preferred flavors and performance of weanling pigs. Journal of Animal Science. 1983;56:1287-1293. https://doi.org/10.2527/jas1983.5661287x.PMID:6874611

7. Avena N.M., Rada P., Moise N., Hoebel B.G. Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response. Neuroscience. 2006;139(3):813-820. https://doi.org/10.1016/j.neuroscience.2005.12.037

8. Kellie A.K., Dane W.F., Ryan P.M., Samer W.E. et. al. Supplementation with artificial sweetener and capsaicin alters metabolic flexibility and performance in heat-stressed and feed-restricted pigs. Journal of Animal Science. 2022;100(8):195. https://doi.org/10.1093/jas/skac195

9. Roura E., Fu M. Taste, Nutrient Sensing and Feed Intake in Pigs (130 Years of Research: Then, Now and Future). Animal Feed Science and Technology. 2017;233:3-12. https://doi.org/10.1016/j.anifeedsci.2017.08.002

10. Daly K., Moran A.W., Al-Rammahi M., Weatherburn D. et al. Non-Nutritive Sweetener Activation of the Pig Sweet Taste Receptor T1R2-T1R3 In Vitro Mirrors Sweetener Stimulation of the Gut-Expressed Receptor In Vivo. Biochemical and Biophysical Research Communications. 2021;542:54-58. https://doi.org/10.1016/j.bbrc.2021.01.032

11. Lei Y., Kim J.K., Tran H.N., Kim I.H. Effect of feed flavor and sweetener on growth performance, nutrient digestibility, blood profile, and diarrhea score in weaning pigs. Korean Journal of Agricultural Science. 2017;44:77-85. https://doi.org/10.7744/kjoas.20170009

12. Chang L., Won Y., Jihwan L., Woo K. et al. Effects of artificial sweeteners on feed palatability and performance in weaned pigs. Canadian Journal of Animal Science. 2018;99:307-314. https://doi.org/10.1139/cjas-2018-0143

13. Daly K., Darby A.C., Hall N., Nau A. et al. Dietary supplementation with lactose or artificial sweetener enhances swine gut Lactobacillus population abundance. British Journal of Nutrition. 2014;111:30-35. https://doi.org/10.1017/S0007114513002274

14. Daly K., Darby A.C., Hall N., Wilkinson M.C. et al. Bacterial Sensing Underlies Artificial Sweetener-induced Growth of Gut Lactobacillus. Environmental Microbiology. 2016;18:2159-2171. https://doi.org/10.1111/1462-2920.12942

15. Sterk A., Schlegel P., Mul A.J., Ubbink-Blanksma M. et al. Effects of sweeteners on individual feed intake characteristics and performance in group-housed weanling pigs. Journal of Animal Science. 2008;86:2990-7. https://doi.org/10.2527/jas.2007-0591

16. Suez J., Korem T., Zilberman-Schapira G., Segal E. et al. Non-caloric artificial sweeteners and the microbiome: findings and challenges. Gut Microbes. 2015;6:149-155. https://doi.org/10.1080/19490976.2015.1017700

17. Wang L.S., Shi Z., Shi B.M., Shan A.S. Effects of Dietary Stevioside/Rebaudioside A on the Growth Performance and Diarrhea Incidence of Weaned Piglets. Animal Feed Science and Technology. 2014;187:104-109. https://doi.org/10.1016/j.anifeedsci.2013.10.014

18. Maenz D.D., Patience J.F., Wolynetz M.S. Effect of Water Sweetener on the Performance of Newly Weaned Pigs Offered Medicated and Unmedicated Feed. Canadian Journal of Animal Science. 1993;73:669-672. https://doi.org/10.4141/cjas93-073

19. Zhu L., Wang G., Dong B., Peng C.C. et al. Effects of sweetener neotame on diet preference, performance and hematological and biochemical parameters of weaned piglets. Animal Feed Science and Technology. 2016;214:86-94. https://doi.org/10.1016/j.anifeedsci.2016.02.013

20. Zhang W., Heng J., Kim S.W., Chen F. et al. Dietary Enzymatically-Treated Artemisia annua L. Supplementation Could Alleviate Oxidative Injury and Improve Reproductive Performance of Sows Reared under High Ambient Temperature. Journal of Thermal Biology. 2020;94:102751. https://doi.org/10.1016/j.jtherbio.2020.102751

21. Bian X., Chi L., Gao B., Tu P. et al. Artificial sweetener acesulfame potassium affects the gutmicrobiome and body weight gain in CD-1 mice. PLoS ONE. 2017;12(6): e0178426. https://doi.org/10.1371/journal.pone.0178426

22. Chi L., Bian X., Gao B., Tu P. et al. Effects of the artificial sweetener neotame on the gut micro-biome and fecal metabolites in mice. Molecules. 2018;23(2):367. https://doi.org/10.3390/molecules23020367

23. Elnaga N.A., Massoud M.I., Yousef M.I., Mohamed H.H. Effect of stevia sweetener consumption as non-caloricsweetening on body weight gain and biochemicas parame-ters in overweight female rats. Annals of Agricultural Sciences. 2016;61:155-163. https://doi.org/10.1016/j.aoas.2015.11.008

24. Juncai C., Yan L., Yang Z., Shiqian H., Lingbin L. et al. Beyond sweetness: The high-intensity sweeteners and farm animals. Animal Feed Science and Technology. 2020;267:114571. https://doi.org/10.1016/j.anifeedsci.2020.114571

25. Aldinger S.M., Speer V.C., Hays V.W., Catron D.V. Effect of saccharin and sucrose on the performance of young pigs. Journal of Animal Science. 1961;20:249-254. https://doi.org/10.1139/CJAS-2018-0143

26. Guzmán-Pino S.A., Solà-Oriol D., Figueroa J., Dwyer D.M. et al. Effect of a long-term exposure to concentrated sucrose and maltodextrin solutions on the preference, appetence, feed intake and growth performance of post-weaned piglets. Physiology and Behavior. 2015;141:85-91. https://doi.org/10.1016/j.physbeh.2015.01.009

27. Wenwei Z., Holden H., Limin G., Wenqing L. et al. Effects of sweetener sucralose on diet preference, growth performance and hematological and biochemical parameters of weaned piglets. Asian-Australasian Journal of Animal Sciences. 2020;5(33):802-811. https://doi.org/10.5713/ajas.18.0863

28. Ochetim S., Odur I.D. The effect of varying the level of saccharin on the performance of young pigs. East African Agricultural and Forestry Journal. 1979;44:202-205. https://doi.org/10.1080/00128325.1979.11663009

29. Glaser D., Wanner M., Tinti J.M., Nofre C. Gustatory responses of pigs to various natural and artificial compounds known to be sweet in man. Food Chemistry. 2000;68:375-385. https://doi.org/10.1016/S0308-8146(99)00212-5

30. Clouard C., Chataignier M., Meunier-Salaün M.-C., Val-Laillet D. Flavour Preference Acquired via a Beverage-Induced Conditioning and Its Transposition to Solid Food: Sucrose but Not Maltodextrin or Saccharin Induced Significant Flavour Preferences in Pigs. Applied Animal Behaviour Science. 2012;136(1):26-36. https://doi.org/10.1016/j.applanim.2011.11.007

31. Yan L., Jang H.D., Kim I.H. Creep Feed: Effects of Feed Flavor Supplementation on Pre- and Post-weaning Performance and Behavior of Piglet and Sow. Asian-Australasian Journal of Animal Sciences. 2011;24(6):851-856. https://doi.org/10.5713/ajas.2011.11011


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For citations:


Maksimov V.I., Volkova M.A., Erkhova K.A. Application of sweeteners in pig feeding: a bibliographic review. Timiryazev Biological Journal. (In Russ.) https://doi.org/10.26897/2949-4710-2025-3-1-4-03

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