Features of hemodynamic regulation in rabbits during parenteral administration of trypsin
https://doi.org/10.26897/2949-4710-2025-3-2-4-01
Abstract
Trypsin is widely used for its proteolytic, anti-inflammatory, and decongestant properties. In this study, we investigated, for the first time, the effects of crystalline trypsin on hemodynamics in rabbits after parenteral administration, aiming to elucidate features of hemodynamic regulation. The study involved 15 rabbits, which received either an intramuscular (IM) or intravenous (IV) administration of trypsin solution at a dose of 0.25 mg/kg body weight. Comparative analysis of hemodynamic parameters revealed that intramuscular administration of crystalline trypsin solution induced a vasodilating effect, accompanied by a significant decrease in blood pressure (13% systolic, 12% diastolic) and an 8% increase in heart rate in rabbits. Intravenous administration of trypsin resulted in a short-term hypotensive effect, which was compensated within 30 minutes by activation of the sympathetic nervous system. These findings enhance our understanding of trypsin’s mechanisms of action on the cardiovascular system and support its potential application in veterinary medicine for correcting microcirculatory disorders.
About the Authors
Semyon D. Galiga
Russian State Agrarian University – Moscow Timiryazev Agricultural Academy
Russian Federation
Russian Federation
Semyon D. Galiga, post-graduate student of the Department of Physiology, Ecology and Biochemistry of Animals, Russian State Agrarian University – Moscow Timiryazev Agricultural Academy; 49 Timiryazevskaya St., Moscow, 127434, Russian Federation
Svetlana V. Karamushkina
Russian State Agrarian University – Moscow Timiryazev Agricultural Academy
Svetlana V. Karamushkina, CSc (Bio), Associate Professor, Associate Professor at the Department of Physiology, Ecology and Biochemistry of Animals, Russian State Agrarian University – Moscow Timiryazev Agricultural Academy; 49 Timiryazevskaya St., Moscow, 127434, Russian Federation
Aleksandra V. Kralinina
Russian State Agrarian University – Moscow Timiryazev Agricultural Academy
Aleksandra V. Kralinina, Laboratory Assistant at the Department of Physiology, Ecology and Biochemistry of Animals, BSc (Bio), Russian State Agrarian University – Moscow Timiryazev Agricultural Academy; 49 Timiryazevskaya St., Moscow, 127434, Russian Federation
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Review
For citations:
Galiga S.D., Karamushkina S.V., Kralinina A.V. Features of hemodynamic regulation in rabbits during parenteral administration of trypsin. Timiryazev Biological Journal. 2025;3(2):202532401. (In Russ.) https://doi.org/10.26897/2949-4710-2025-3-2-4-01
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